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Epithelial-specific ERBB3 deletion results in a genetic background-dependent increase in intestinal and colon polyps that is mediated by EGFR.
Mantilla Rojas C, McGill MP, Salvador AC, Bautz D, Threadgill DW. Mantilla Rojas C, et al. PLoS Genet. 2021 Nov 29;17(11):e1009931. doi: 10.1371/journal.pgen.1009931. eCollection 2021 Nov. PLoS Genet. 2021. PMID: 34843459 Free PMC article.
To confirm a previous study showing intestinal polyps are dependent upon ERBB3, we generated an intestinal epithelia-specific ERBB3 deletion in C57BL/6-ApcMin/+ mice. Contrary to the previous report showing a significant reduction in intestin …
To confirm a previous study showing intestinal polyps are dependent upon ERBB3, we generated an intestinal epith …
Kinase activity of ERBB3 contributes to intestinal organoids growth and intestinal tumorigenesis.
Nguyen AT, Lee SY, Chin HJ, Le QV, Lee D. Nguyen AT, et al. Cancer Sci. 2020 Jan;111(1):137-147. doi: 10.1111/cas.14235. Epub 2019 Dec 13. Cancer Sci. 2020. PMID: 31724799 Free PMC article.
However, the biological function of ERBB3 kinase activity remains elusive in vivo. Here we have identified the physiological function of inactivated ERBB3 kinase activity by creating Erbb3-K740M knockin mice in which ATP cannot bind to ERBB3. ...Taken …
However, the biological function of ERBB3 kinase activity remains elusive in vivo. Here we have identified the physiological function …
Prophylactic vaccination targeting ERBB3 decreases polyp burden in a mouse model of human colorectal cancer.
Bautz DJ, Sherpa AT, Threadgill DW. Bautz DJ, et al. Oncoimmunology. 2016 Dec 7;6(1):e1255395. doi: 10.1080/2162402X.2016.1255395. eCollection 2017. Oncoimmunology. 2016. PMID: 28197371 Free PMC article.
Administration of the peptide resulted in a significant decrease in the development of intestinal polyps in C57BL/6J-Apc(Min) mice, a model of familial adenomatous polyposis (FAP). ...These results indicate that prophylactic vaccination targeting ERBB3 could …
Administration of the peptide resulted in a significant decrease in the development of intestinal polyps in C57BL/6J-Apc(Min) …